NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation
Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells.Depending on local signals, SVZ can generate new neurons, astrocytes or oligodendrocytes.We previously demonstrated that activation of NMDA receptors in SVZ progenitors increases the rate of oligodendrocyte differentiation.Here w